481 Relationship between skin and subcutaneous tissue biomechanics and thickness in healthy subjects

The handheld Myoton device has been useful in a broad array of skin and soft tissue disease by measuring five biomechanical parameters: stiffness, frequency, relaxation time, decrement, creep. To understand the effect anatomy on these clinical biomarkers, we investigated relationship between parameters both (epidermis dermis) subcutaneous thickness measured High-Frequency Ultrasound (HFUS). We biomechanics bilaterally volar forearm healthy participants (n=11, age range: 19 -72) with Myoton. imaged each site VevoMD HFUS (48 MHz linear probe) device. Correlations were examined assessed from B-mode images. Mean at was 1.26 ± 0.04 mm. 4.80 0.14 stiffness (Spearman ρ = -0.83, p <0.001), frequency (-0.80, time (0.76, p<0.001) had significant correlations 22 forearms. By contrast, far weaker for thickness. Easily objectively acquired provide insights into This finding supports use as an anatomically validated method to monitor responses new therapeutic regimens fibrosing diseases, including chronic graft-vs-host scleroderma, which traditionally rely subjective exams decision-making.